Summer in Paris: NASH Update

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No Acceptable Surrogates for NASH Cirrhosis

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Therapy for NASH Cirrhosis is a Distant Hope

NASH is a chronic liver disorder that results in progressive fibrosis, ultimately culminating in some patients in liver cirrhosis. In cirrhosis, the fibrotic scar tissue distorts the normal liver...
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Is Gilead’s Selonsertib for NASH Dead?

Title: Is Gilead’s Selonsertib for NASH Dead? Author: Peter G. Traber, MD Date: 02/12/2019 Introduction The search for an effective therapy for NASH with advanced fibrosis/cirrhosis suffered a major...
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Orkambi UK - Sound and Fury

By Anthony Walker, PhD, Managing Partner There’s a lot of sound and fury about Orkambi in the UK. Following a rejection from NICE, Vertex and NHS England have not been able to reach terms and the...
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Why Every Biotech Needs a Scouting Function

Title: Why Every Biotech Needs a Scouting Function Author: Chris Owens, PhD What is asset scouting? Simply put, it is a search to identify and evaluate pharmaceutical assets or partners for...
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microRNAs as drug targets

microRNAs as drug targets Saadia Basharat, PhD, Senior Consultant microRNAs (miRNA) are small noncoding RNAs that regulate the expression of multiple target genes by either blocking the translation...
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Infographic: Britain crashes out of favor with US pharmaceutical executives

Britain crashes out of favor with US pharmaceutical executives The biotech industry is a pillar of the knowledge economy, with governments around the world investing heavily to attract capital and...
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NASH Surprises and Interpretation of Clinical Trials

Title: NASH Surprises and Interpretation of Clinical Trials Author: Peter G. Traber, MD Introduction 2019 will usher in a new chapter in NASH drug development with data reported on the first phase 3...
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Pharma Defying Gravity – How Much Longer?

Anthony Walker, PhD, Managing Partner, Alacrita Consulting
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Routes to European Commercialisation in Europe

Title: Routes to Commercialisation in Europe Author: Anna Casse, Managing Partner Abstract In the past it was not extraordinary for US biotech companies to develop drugs in the US and to launch them...
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Agencies Clarify NASH Endpoints—But Don’t Harmonize

Title: Agencies Clarify NASH Endpoints—But Don’t Harmonize Author: Peter G. Traber, MD The FDA and EMA have recently published very similar clinical trial endpoints for pre-cirrhotic NASH, with one...
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