A Patient-Reported Outcomes Analysis Of Lanreotide In The Treatment Of NETs Patients With Carcinoid Syndrome

11th November 2019
The purpose of this analysis of patient-reported outcomes from the ELECT (Evaluation of Lanreotide Depot/Autogel Efficacy and Safety as a Carcinoid Syndrome Treatment) trial (NCT00774930) was to...
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Valuing Pharmaceutical Assets: When to Use NPV vs rNPV

15th October 2019
Preview: A variety of approaches have been developed to evaluate pharmaceutical assets, but two similar yet distinct methods are most commonly used. Venture capitalists and large investment firms...
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Adeno-Associated Virus Gene Therapy Landscape

24th September 2019
Adeno-associated viruses (AAV) are virus particles composed of single-stranded DNA surrounded by a protein shell. Despite their simple structure, recombinant AAVs (rAAV) can perform the important...
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Due Diligence: The Pinnacle of Expertise-Based Consulting

23rd August 2019
The Basics Due diligence, the formal exercise of quantifying risks and confirming value, has been described as “Art meets Science” and there’s a lot of truth in that. To some, it’s simply a question...
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FDA Expedited Programs for Cancer Drug Development: Don’t Believe the Doubters

16th August 2019
Intro:  
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Pharmaceutical Patent Term Extension: An Overview

27th March 2019
Pharmaceutical Patent Term Extension: An Overview About the authors: Scott Whittaker is an Alacrita Associate and Robert Johnson is Managing Partner of the firm’s Boston office. Anthony Walker is a...
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Pharmaceutical Probability of Success

19th October 2018
Abstract: Critical strategic decisions are made based on valuation models of pharmaceutical assets. Of the many assumptions that underpin a valuation model, probability of success is a key input, but...
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Leveraging Diagnostics to Realize the Full Potential of Precision Oncology

07th July 2017
As we approach the twentieth anniversary of the approval of Herceptin, the field of precision oncology has never been more exciting or dynamic, and utility seems to be broadly recognized. Precision...
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Commercialisation of Cellular Immunotherapies

07th May 2016
Commercialisation of Cellular Therapies Biochemical Society Transactions Apr 11, 2016,44(2)329-332; DOI: 10.1042/BST20150240 Abstract Successful commercialization of a cell therapy requires more than...
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What's wrong with NPV valuations?

26th October 2015
Risk-adjusted NPV is Notoriously Fallible Over at least the past decade, risk-adjusted Net Present Value (rNPV) has emerged as the de facto standard for valuing pharmaceutical R&D projects (1,2)....
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Medtech: how to succeed in Europe

20th March 2014
Amidst a currently effervescent biotech scene, medtech is suffering. Sector newsflow is dominated by layoffs, regulatory escalation and a harsh fiscal environment. In this context, it is appealing...
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It is critical for US biotech companies to understand the needs of European payers

17th October 2013
There is increasing divergence between the evidence regulators need for approval, and that needed by payers for reimbursement. Whilst ignoring the needs of European payers before entering Phase 3...
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